5/28/2017 0 Comments Diindolyl Methane For Weight LossDIINDOLYLMETHANE: Uses, Side Effects, Interactions and Warnings. References: Wattenberg, L. Inhibition of polycyclic aromatic hydrocarbon- induced neoplasia by naturally occurring indoles. Dietary constituents altering the responses to chemical carcinogens. Wihlen, B., Ahmed, S., Inzunza, J., and Matthews, J. Estrogen receptor subtype- and promoter- specific modulation of aryl hydrocarbon receptor- dependent transcription. E., Katchamar, S., Larsen- Su, S. Concurrent flavin- containing monooxygenase down regulation and cytochrome P4. E., Noordhoek, J., and Blaauboer, B. Acid reaction products of indole- 3- carbinol and their effects on cytochrome P4. II enzymes in rat and monkey hepatocytes. M., van der Linden, E.
A., Noordhoek, J., Blaauboer, B. Effects of indole- 3- carbinol on biotransformation enzymes in the rat: in vivo changes in liver and small intestinal mucosa in comparison with primary hepatocyte cultures. Xue, L., Firestone, G. DIM stimulates IFNgamma gene expression in human breast cancer cells via the specific activation of JNK and p. Oncogene 3- 3. 1- 2. J., Li, M., Firestone, G. Diindolylmethane stimulates murine immune function in vitro and in vivo. Yin, H., Chu, A., Li, W., Wang, B., Shelton, F., Otero, F., Nguyen, D. Lipid G protein- coupled receptor ligand identification using beta- arrestin Path. Hunter assay. 5- 1- 2. Down- regulation of c- FLIP contributes to the sensitization effect of 3,3'- diindolylmethane on TRAIL- induced apoptosis in cancer cells. Effects of treatment of rats with indole- 3- carbinol on apoptosis in the mammary gland and mammary adenocarcinomas. Find patient medical information for DIINDOLYLMETHANE on WebMD including its uses, effectiveness, side effects and safety, interactions, user ratings and products. Fenugreek can not only add some spice and flavor to your foods, but it is also useful to support general health and wellness.* Fenugreek is also sometimes used by. Looking for a superantioxidant to help prevent cancer and other chronic diseases? Diindolymethane (DIM) may be the supplement for you. It’s both an antioxidant and. B): 2. 47. 3- 2. 47. N., Yu, H., Li, Y., and Zhao, X. Zhonghua Yi. Xue. Za Zhi. 3- 1. 1- 2. View abstract. Aggarwal, B. Molecular targets and anticancer potential of indole- 3- carbinol and its derivatives. Cell Cycle 2. 00. View abstract. Balk JL. Altern Med Alert 2. Bonnesen C, Eggleston IM, Hayes JD. Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines. Cancer Res 2. 00. View abstract. Bradlow HL, Sepkovic DW, Telang NT, Osborne MP. View abstract. Chen I, Mc. Dougal A, Wang F, Safe S. View abstract. Chen I, Safe S, Bjeldanes L. View abstract. Dalessandri, K. Pilot study: effect of 3,3'- diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early- stage breast cancer. Nutr Cancer 2. 00. View abstract. Firestone, G. Indole- 3- carbinol and 3- 3'- diindolylmethane antiproliferative signaling pathways control cell- cycle gene transcription in human breast cancer cells by regulating promoter- Sp. J Nutr 2. 00. 3; 1. Suppl): 2. 44. 8S- 2. Diindolylmethane (DIM) is a compound derived from the digestion of indole-3-carbinol (I3C), found in cruciferous vegetables such as broccoli, Brussels sprouts, and. Because DHEA levels decrease with age, people above middle age are some of the best candidates for DHEA supplementation. As we age, our bodies become less efficient. S. View abstract. Ge X, Yanni S, Rennert G, et al. Biochem Biophys Res Commun 1. View abstract. Lake BG, Tredger JM, Renwick AB, et al. View abstract. Mc. Dougal A, Gupta MS, Ramamoorthy K, et al. View abstract. Natl Inst Health, Natl Inst Environmental Health Sci. Botanicals in cancer chemoprevention. Cancer Metastasis Rev 2. View abstract. Riby JE, Chang GHF, Firestone GL, Bjeldanes LF. Abdelrahim, M., Newman, K., Vanderlaag, K., Samudio, I., and Safe, S. DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress- dependent upregulation of DR5. Carcinogenesis 2. Acharya, A., Das, I., Singh, S., and Saha, T. Chemopreventive properties of indole- 3- carbinol, diindolylmethane and other constituents of cardamom against carcinogenesis. Recent Pat Food Nutr. Agric. Ahmad, A., Kong, D., Sarkar, S. H., Wang, Z., Banerjee, S., and Sarkar, F. Inactivation of u. PA and its receptor u. PAR by 3,3'- diindolylmethane (DIM) leads to the inhibition of prostate cancer cell growth and migration. Ahmad, A., Kong, D., Wang, Z., Sarkar, S. H., Banerjee, S., and Sarkar, F. Down- regulation of u. PA and u. PAR by 3,3'- diindolylmethane contributes to the inhibition of cell growth and migration of breast cancer cells. Anticancer properties of indole compounds: mechanism of apoptosis induction and role in chemotherapy. Physiological effects of cabbage with reference to its potential as a dietary cancer- inhibitor and its use in ancient medicine. Ali, S., Banerjee, S., Ahmad, A., El- Rayes, B. Apoptosis- inducing effect of erlotinib is potentiated by 3,3'- diindolylmethane in vitro and in vivo using an orthotopic model of pancreatic cancer. Ali, S., Banerjee, S., Schaffert, J. Concurrent inhibition of NF- kappa. B, cyclooxygenase- 2, and epidermal growth factor receptor leads to greater anti- tumor activity in pancreatic cancer. Ali, S., Varghese, L., Pereira, L., Tulunay- Ugur, O. E., Kucuk, O., Carey, T. Sensitization of squamous cell carcinoma to cisplatin induced killing by natural agents. J., Jukes, R., Lamb, J. M., Gescher, A., Steward, W. Liquid chromatographic assay for the simultaneous determination of indole- 3- carbinol and its acid condensation products in plasma. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. D., Gescher, A., Lamb, J. Pharmacokinetics and tissue disposition of indole- 3- carbinol and its acid condensation products after oral administration to mice. M., Verschoyle, R., Gescher, A., Steward, W. Physiological modeling of formulated and crystalline 3,3'- diindolylmethane pharmacokinetics following oral administration in mice. B., Sanchez- Bravo, J., and Acosta, M. Indole- 3- carbinol as a scavenger of free radicals. J., Fan, S., Rosen, E. M., Goodwin, L., Chandraskaren, A., Williams, D. E., Chen, D., and Carter, T. Indole- 3- carbinol is a negative regulator of estrogen. Suppl): 2. 47. 0S- 2. S. S., Ahmad, A., Banerjee, S., Rangnekar, V. Chemoprevention of pancreatic cancer: characterization of Par- 4 and its modulation by 3,3' diindolylmethane (DIM). H., Wen, R., Zheng, J. Anticarcinogenic and antioxidant activity of diindolylmethane derivatives. Bhatnagar, N., Li, X., Chen, Y., Zhou, X., Garrett, S. Cancer Prev. Res.(Phila) 2. M., Li, Y., Banerjee, S., Ahmed, F., Wang, Z., Ali, S., and Sarkar, F. Down- regulation of androgen receptor by 3,3'- diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in both hormone- sensitive LNCa. P and insensitive C4- 2. B prostate cancer cells. J., and Peijnenburg, A. Screening of synthetic and plant- derived compounds for (anti)estrogenic and (anti)androgenic activities. Structure- activity relationships of dietary indoles: a proposed mechanism of action as modifiers of xenobiotic metabolism. J. Toxicol. Environ. Health 1. 98. 7; 2. Diindolylmethane (DIM) spontaneously forms from indole- 3- carbinol (I3. C) during cell culture experiments. In Vivo 2. 01. 0; 2. H., Liu, K., Ralph, W., Jr., Chen, D., Qi, M., Fan, S., Yuan, F., Rosen, E. Diindolylmethane alters gene expression in human keratinocytes in vitro. Chang, X., Firestone, G. Inhibition of growth factor- induced Ras signaling in vascular endothelial cells and angiogenesis by 3,3'- diindolylmethane. Carcinogenesis 2. Diindolylmethane inhibits angiogenesis and the growth of transplantable human breast carcinoma in athymic mice. Carcinogenesis 2. C., Riby, J., Chang, G. C., Firestone, G., and Bjeldanes, L. Cytostatic and antiestrogenic effects of 2- (indol- 3- ylmethyl)- 3,3'- diindolylmethane, a major in vivo product of dietary indole- 3- carbinol. Z., Qi, M., Auborn, K. Indole- 3- carbinol and diindolylmethane induce apoptosis of human cervical cancer cells and in murine HPV1. Chen, I., Hsieh, T., Thomas, T., and Safe, S. Identification of estrogen- induced genes downregulated by Ah. R agonists in MCF- 7 breast cancer cells using suppression subtractive hybridization. Gene 1- 1. 0- 2. 00. Chen, Y., Xu, J., Jhala, N., Pawar, P., Zhu, Z. Fas- mediated apoptosis in cholangiocarcinoma cells is enhanced by 3,3'- diindolylmethane through inhibition of AKT signaling and FLICE- like inhibitory protein. Chinnakannu, K., Chen, D., Li, Y., Wang, Z., Dou, Q. Cell cycle- dependent effects of 3,3'- diindolylmethane on proliferation and apoptosis of prostate cancer cells. J. Cell Physiol 2. Chintharlapalli, S., Papineni, S., and Safe, S. LNCa. P prostate cancer cells through peroxisome proliferator- activated receptor gamma- independent pathways. Chintharlapalli, S., Smith, R., III, Samudio, I., Zhang, W., and Safe, S. Bis(3'- indolyl)- 1- (p- substitutedphenyl)methanes induce peroxisome proliferator- activated receptor gamma- mediated growth inhibition, transactivation, and differentiation markers in colon cancer cells. Diindolylmethane suppresses the inflammatory response to lipopolysaccharide in murine macrophages. O., Chintharlapalli, S., Abdelrahim, M., Khan, S., Yoon, K., Kamat, A. Activation of nerve growth factor- induced B alpha by methylene- substituted diindolylmethanes in bladder cancer cells induces apoptosis and inhibits tumor growth. D., Lei, P., Abdelrahim, M., Yoon, K., Liu, S., Guo, J., Papineni, S., Chintharlapalli, S., and Safe, S. Nur. 77- independent proapoptotic responses in colon cancer cells. O., Chintharlapalli, S., Safe, S., Abdelrahim, M., Kong, G., Choi, H. The p. 38 MAPK pathway is critical for 5,5'- dibromodiindolylmethane- induced apoptosis to prevent oral squamous carcinoma cells. Contractor, R., Samudio, I. J., Estrov, Z., Harris, D., Mc. Cubrey, J. H., Andreeff, M., and Konopleva, M. A novel ring- substituted diindolylmethane,1,1- bis. Indole- 3- carbinol, but not its major digestive product 3,3'- diindolylmethane, induces reversible hepatocyte hypertrophy and cytochromes P4. Toxicol. Appl. Pharmacol. Anticarcinogenic activity of indole- 3- carbinol acid products: ultrasensitive bioassay by trout embryo microinjection. H., Uyetake, L., Fong, A. In vivo disposition of the natural anti- carcinogen indole- 3- carbinol after po administration to rainbow trout. E., Noordhoek, J., Blaauboer, B. J., and Wortelboer, H. Structure elucidation of acid reaction products of indole- 3- carbinol: detection in vivo and enzyme induction in vitro. J., Selmin, O., and Romagnolo, D. DIM for Hormone Balance: A Super Supplement! DIM (diindolylmethane), is a food- based compound found in cruciferous vegetables like broccoli, cabbage, cauliflower and Brussel’s sprouts. Studies have shown that it has the ability to reduce the risk of certain cancers, especially those influenced by excessive estrogen levels, such as breast, uterine and prostate. DIM can also stimulate fat breakdown and encourage an increase in muscle mass. I can attest, through my own personal experience supplementing with DIM as well as that of quite a few clients (both male and female), that DIM effectively modulates estrogen metabolism – helping to do away with uncomfortable symptoms of PMS, perimenopause and prostate issues. So using DIM for hormone balance can be very effective. The following excerpt comes from Dr. Scott Rollins, MD, founder and Medical Director at the Integrative Medicine Center of Western Colorado (http: //imcwc. This is a very well- written and comprehensive account of the effects of DIM and how to best use this supplement to make the most out of its incredible benefits. Lower your risk of cancer, help lose weight and build muscle – all remarkable benefits of a simple food supplement called DIM. For men or women, DIM is something to consider as part of an overall supplement program. DIM, or diindolylmethane, is a plant based compound found in cruciferous vegetables, such as brussel sprouts,cabbage, broccoli and cauliflower. DIM has been shown in studies to reduce the risk of certain cancers, especially those driven by abnormally high estrogen levels, such as breast, uterus and prostate cancer. DIM can also stimulate the breakdown of fat while encouraging muscle development. DIM for Hormone Balance and Estrogen Overload. Estrogen hormones are naturally found in men and women and have many benefits such as preserving artery health and brain function while fighting oxidative free radical damage. Higher estrogen levels found in women cause the female body shape with breast and hip development. Many women are estrogen dominant however, meaning they have too much estrogen accumulating in the body for the complementary progesterone to balance. Natural estrogen dominance occurs as women near menopause, starting even ten years prior to menopause, where they often don’t make as much progesterone to balance their estrogen. Symptoms such breast pain, water retention, heavy painful menstrual cycles, or irritable anxious moods are typical bothersome symptoms. Estrogen’s over- stimulation of breasts and uterus tissue can lead to breast cysts or adenomas and uterine growths – both unpleasant and potentially dangerous physical outcomes are too often accompanied by worrisome mammograms and hysterectomies. Some women have estrogen dominance throughout their life for various reasons, such as low thyroid, high cortisol, exposure to environmental estrogen- like chemicals, or impaired detoxification pathways for estrogen. Men often suffer from estrogen overload as well. With normal aging our testosterone levels drop as the conversion to estrogen increases, leading to a falling ratio of testosterone to estrogen. Higher estrogen levels in men lead to weight gain, loss of muscle mass, feminization of the body, further decreases in already falling testosterone levels, and increase the risk of diseases such as heart disease and prostate cancer. The enzyme that normally converts testosterone to estrogen is most abundant in fat, so as men put on weight the cycle of falling testosterone and rising estrogen simply picks up steam! How does DIM work? There are two main pathways in the liver for our estrogen to be normally metabolized and excreted. One pathway leads to very good metabolites called 2- hydroxy estrogens. The other pathway leads to bad metabolites called 4 or 1. DIM stimulates the favorable 2- hydroxy pathway for estrogen metabolism and this is how DIM works to improve our health. DIM is not a hormone, nor is it a hormone replacement. It is a plant compound that will improve our hormone balance. By improving the metabolism of our natural estrogens DIM will help lower high levels of estrogen in the body. This alone can help remedy estrogen dominant conditions and restore a healthy estrogen/testosterone ratio in men and women. The favorable 2- hydroxy metabolites promoted by DIM are potent anti- oxidants and help prevent muscle breakdown after exercise, as evidenced by female athletes having less muscle tissue breakdown after intense exercise than men. By reducing the estrogen dominance and also reducing the accumulation of cancer- promoting 4/1. DIM can help lower the risk of cancer. The 2- hydroxy metabolites help increase the active testosterone levels in men and women by displacing inactive protein- bound testosterone to its active “free” portion. This leads to significant improvements in the ability to build muscle and enjoy the benefits of testosterone including better mood, increased stamina, endurance, sex drive and erectile function. The accumulation of fat around the belly, hips and buttocks is partly due to excess estrogen levels combined with falling testosterone levels. DIM will help lower excess estrogen and promote the fat- burning 2- hydroxy metabolites. This can help you achieve a leaner body with less body fat.
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